Nya fas I kliniska data på antikroppen CAN04 (nidanilimab) presenterades idag som en muntlig presentation på konferensen ”2019 ASCO Annual Meeting”. Data från 22 patienter visar att CAN04-behandling är förenat med god säkerhet.

CAN04 increased the anti-tumor effects in mice when combined with different registered platinum-based therapies (cisplatin, carboplatin or oxaliplatin) in either a patient-derived NSCLC model or mouse colon cancer model. Enhanced effects of CAN04 was also observed in combination with two commonly used platinum doublets, cis/gem and oxaliplatin/5-FU.

IL1RAP återfanns i tumörens mikromiljö i samtliga prover och cirka 80 % av patienterna hade IL1RAP-positiva cancerceller. Cantargia Presents New Preclinical Data on CAN04 at the 2020 AACR Annual Meeting. PRESS RELEASE PR Newswire . Jun. 22, 2020, 03:13 PM "Vi är glada över att kunna presentera nya data på CAN04 i kombination med cellgifter på denna viktiga cancerkonferens. Det bekräftar Cantargias engagemang att förse patienter som har livshotande sjukdomar med nya, innovativa och säkra terapeutiska möjligheter", sa Göran Forsberg, VD på Cantargia. Cantargia AB: Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting Publicerad: 2020-05-15 (Cision) Måndag 4 maj 2019-06-02 · CAN04 is a humanized and antibody-dependent cellular cytotoxicity (ADCC)-enhanced IgG1 antibody targeting IL1RAP with two modes of action: blocking IL-1 alpha and beta signaling and triggering ADCC. This study included 22 patients with non–small cell lung cancer (NSCLC; four patients), pancreatic ductal adenocarcinoma (six patients), or colorectal cancer (12 patients).

Not only data transmission, VTC7220- extension of the license agreement around the BioWa proprietary POTELLIGENT® Technology for production of Cantargia's antibody drug candidate CAN04, 23 aug 2019 Bioteknikbolaget meddelar positiva preklindata för kandidaten CAN04 i urinblåsecancer. Oct 8, 2013 The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. CAN-04-2033. Apr 3, 2018 Note: Male share of total parental leave is from 2015 and female leadership data is from 2016. 1Leadership positions defined as legislators, 10 mar 2021 Cantargia's lead asset CAN04 (anti-IL1RAP) is a potential competitor. While we acknowledge that Novartis's data has created negative Mar 22, 2021 Data that is produced by monitoring probes is stored in the UIM database, in tables named raw data tables (table prefix is RN_).

Our development program includes the product candidate CAN04, presented novel preclinical data on antibody cantargia kurs CAN04 at the

The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. reported data from 1 patient in the Phase I/IIa CANFOUR trial showing that once-weekly IV CAN04..adverse events. The first part of the open-label, European trial is evaluating escalating doses of CAN04..pancreatic cancer, colorectal cancer or triple-negative breast cancer (TNBC), and the second part will evaluate CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP).

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Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda. Cantargia AB: Cantargia presents new preclinical data on CAN04 in combination with chemotherapy at the 2020 AACR Annual Meeting. Publicerad: 2020-05-15 (Cision) Cantargia AB: Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting. Publicerad: 2020-05-15 (Cision) Cantargia AB (publ) today presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab) in a poster presentation at the ESMO Congress 2018 in Munich, Germany. Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented. Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda.

”Vi är glada över att kunna presentera nya data på CAN04 i kombination med cellgifter på denna viktiga cancerkonferens. Det bekräftar Cantargias engagemang att förse patienter som har livshotande sjukdomar med nya, innovativa och säkra terapeutiska möjligheter”, sa Göran Forsberg, VD på Cantargia. Antikroppen CAN04 binder IL1RAP med hög affinitet och fungerar både genom s.k. Antibody-Dependent Cellular Cytotoxicity (ADCC) samt blockad av interleukin-1 signalering. CAN04 studeras för närvarande i en öppen trearmad fas I/IIa klinisk prövning, CANFOUR. About CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1α and IL-1β signaling.
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During 2019, Cantargia also reported positive preclinical data on the combination of CAN04 and platinum-based compounds. The new results presented at AACR show both parts of the IL-1 system to be upregulated in the tumor tissue in mice after treatment with the chemotherapy doublet cisplatin/gemcitabine (cis/gem) which is clinically used in the CANFOUR study. Cantargia announce positive preclinical data on CAN04 in bladder cancer. Cantargia AB today announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer.

CAN04 is investigated in an open label phase I/IIa clinical trial, Preclinical data show that CAN04 increases the efficacy of chemotherapy. CAN04 is investigated in a phase I/IIa clinical trial, CANFOUR, Cantargia announce positive preclinical data on CAN04 in bladder cancer.
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STOCKHOLM, June 22, 2020 /PRNewswire/ -- Cantargia AB ("Cantargia") today presented new preclinical data giving additional knowledge around the mechanisms and thereby relevance of adding the

Publicerad: 2020-05-15 (Cision) Cantargia AB (publ) today presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab) in a poster presentation at the ESMO Congress 2018 in Munich, Germany. Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented. Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda. Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin-1 receptor accessory protein (IL1RAP).

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Cantargia AB meddelar idag nya positiva prekliniska data som innebär ytterligare en ny utvecklingsmöjlighet för Cantargias antikropp CAN04. Målmolekylen för CAN04, IL1RAP, har påvisats på cancercellerna hos cirka 80 % av patienterna med urinblåsecancer.

reported data from 1 patient in the Phase I/IIa CANFOUR trial showing that once-weekly IV CAN04..adverse events. The first part of the open-label, European trial is evaluating escalating doses of CAN04..pancreatic cancer, colorectal cancer or triple-negative breast cancer (TNBC), and the second part will evaluate CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment. · Both parts of the IL-1 system are upregulated in tumor tissue after chemotherapy · CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different | January 10, 2021 About CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1a and IL-1ß signaling.

The new results show that similar modifications can be introduced in mouse surrogate antibodies. Afucosylation of murine antibodies leads to enhanced binding to receptors present on immune cells, a stronger immune-cell mediated killing and a more pronounced antitumor effect. Cantargia AB meddelar idag nya positiva prekliniska data som innebär ytterligare en ny utvecklingsmöjlighet för Cantargias antikropp CAN04.